Product Identification

Product Name

3-(3-Indolyl)-2-oxopropanoic acid

Synonyms

1H-Indole-3-propanoic acid, alpha-oxo
1H-Indole-3-pyruvic acid
3-Indolylpyroracemic acid
b-Indolepyruvic acid
Indole-3-pyruvic acid
Indolyl-3-pyruvate

CAS

392-12-1

Formula

C11H9NO3

Molecular Weight

203.19

EINECS

206-874-1

RTECS

NM1880000

RTECS Class

Mutagen

Beilstein/Gmelin

172966

Beilstein Reference

5-22-06-00324

Physical and Chemical Properties

Appearance

Slightly beige powder.

Solubility in water

Very soluble

Melting Point

215

pKa/pKb

2.61 (pKa)

Partition Coefficient

.67

Vapor Density

7.01

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from light. Store under an inert atmosphere.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Handle under an inert atmosphere. Store protected from air.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere.

Stability and Reactivity

Incompatibilities

Air, direct light, strong oxidizing agents.

Stability

Stable under normal temperatures and pressures. Air sensitive Light sensitive.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.