Product Identification

Product Name

3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin

Synonyms

2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)
2-Hydroxy-3-(3-oxo-1-phenylbutyl)chromen-4-one
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
Coumafene
Prothromadin

CAS

81-81-2

Formula

C19H16O4

Molecular Weight

308.33

EINECS

201-377-6

RTECS

GN4550000

RTECS Class

Agricultural Chemical and Pesticide; Reproductive Effector; Human Data

Merck

12,10174

Beilstein/Gmelin

1293536

Beilstein Reference

5-18-04-00162

EC Index Number

607-056-00-0

EC Class

Toxic for reproduction Category 1; Toxic; Dangerous for the Environment

Physical and Chemical Properties

Appearance

Colorless crystals.

Solubility in water

20 mg/L

Melting Point

167 - 168

Boiling Point

515

Vapor Pressure

2E-11 (25 C)

pKa/pKb

4.50 (pKa)

Partition Coefficient

2.52

Heat Of Vaporization

82.9 kJ/mol

Usage

Rodenticide for norway rats & for house mice.

Vapor Density

10.6

First Aid Measures

Ingestion

Seek medical assistance.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.

Skin

Remove and isolate contaminated clothing and shoes. Remove material from skin immediately. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.

Eyes

Immediately flush with running water for at least 20 minutes.

Handling and Storage

Storage

Store at away from heat and open flame. Do not store near feeds and foodstuffs and keep away from children, domestic animals, pets, or wildlife.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Effects of contact or inhalation may be delayed.

Skin

Warfarin may be absorbed through the skin and cause systemic poisoning.

Eyes

See Inhalation.

Ingestion

Abdominal pain, vomiting, gastrointestinal bleeding, hemoptysis, and bloody or melenotic stools may occur.

Hazards

Contact with strong oxidizers may cause fires and explosions. Toxic gases and vapors (e.g., carbon monoxide) may be released in heating to decomposition. Avoid strong oxidizers.

UN (DOT)

3027

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate protective gloves, clothing and goggles.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Exposure Effects

Intracranial hemorrhage and hematomyelia may occur following warfarin therapy. The use of warfarin during pregnancy has been associated with teratogenic effects. <br>Fetal intraventricular hemorrhage has been reported following maternal ingestion of warfarin. <br>Craniofacial, musculoskeletal, skin, eye, gastrointestinal, and cardiovascular developmental abnormalities have been observed in the offspring of women administered warfarin sodium during pregnancy. <br>Intrauterine fetal demise, intrauterine growth retardation, and hemorrhagic disease of the newborn have been reported following administration of warfarin sodium to pregnant women.

Exposure limit(s)

TLV: ppm; 0.1 mg/m3 (as TWA) (ACGIH 1991-1992). OSHA PEL: TWA 0.1 mg/m3 NIOSH REL: TWA 0.1 mg/m3 NIOSH IDLH: 100 mg/m3

Poison Class

2

Fire Fighting Measures

Flash Point

188

Fire Fighting

(Non-Specific -- Poison B Solid) Wear full protective clothing and self-contained breathing apparatus.(Non-Specific -- Poison B Solid) Extinguish fire using agent suitable for type of surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical.

Fire Potential

Contact with strong oxidizers may cause fires and explosions.

Accidental Release Measures

Small spills/leaks

Do not touch spilled material. Eating and smoking should not be permitted in areas where it is handled, processed or stored. For small spills: sweep onto paper or other suitable material. Place in an appropriate container and burn in a safe place. Large quantities may be destroyed by dissolving in a flammable solvent (e.g., alcohol) and atomizing in a combustion chamber.

Stability and Reactivity

Stability

Contact with strong oxidizers may cause fires and explosions.

Incompatibilities

Incompatible with the following: Strong oxidizers.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3027

Hazard Class

6.1

Packing Group

I; II; III