Product Identification

Product Name

2-Acetamido-5-sulfamoyl-1,3,4-thiadiazole

Synonyms

2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
5-Acetamide-1,3,4-thiadiazole-2-sulfonamide
Acetamidothiadiazolesulfonamide
Acetamox
Acetazolamid

CAS

59-66-5

Formula

C4H6N4O3S2

Molecular Weight

222.25

EINECS

200-440-5

RTECS

AC8225000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

13,54

Beilstein/Gmelin

212994

Beilstein Reference

4-27-00-08219

Physical and Chemical Properties

Appearance

White to yellowish-white fine crystalline powder. No odor or taste.

Solubility in water

Insoluble

Melting Point

258-259

Density

1.771 g/cm3 (20 C)

pKa/pKb

6.80 (pKb)

Usage

Pharmaceutical.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Store between 15 and 30C (59 and 86F), in a well-closed container, unless otherwise specified by manufacturer.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction.

EC Risk Phrase

R 61

EC Safety Phrase

S 45 53

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Exposure Effects

in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible.

Fire Fighting Measures

Fire Fighting

Fires involving this chemical can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability

Sensitive to light.

Incompatibilities

Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents Flammable gases are formed by mixing materials in this group with alkali metals Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Transport Information

UN Number

2811