Product Identification

Product Name

1,2-Dichloropropane

Synonyms

2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine, cevane-3,4,12,14,16,17,20-heptol deriv.
3-Veratroylveracevine
4,9-Epoxycevane-3,4,12,14,16,17,20-heptol 3-(3,4-dimethoxybenzoate)
Cevane-3,4,12,14,16,17,20-heptol, 4,9-epoxy-, 3-(3,4-dimethoxybenzoate), (3B,4A,16B)-
Dichloropropane
Propylene dichloride
Veratrine

CAS

71-62-5

CAS

78-87-5

Formula

C36H51NO11

Formula

C3H6Cl2

Molecular Weight

112.99

Molecular Weight

673.8

EINECS

200-758-4

EINECS

201-152-2

RTECS

TX9625000

RTECS

YX5600000

RTECS Class

Natural Product

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector; Primary Irritant

Merck

12,10087

Merck

12,8039

Beilstein/Gmelin

1718880

Beilstein/Gmelin

78875

Beilstein Reference

4-01-00-00195

Beilstein Reference

5-21-13-00709

EC Index Number

602-020-00-0

EC Class

Highly flammable; Harmful

Physical and Chemical Properties

Appearance

Colorless liquid with a sweet odor.

Appearance

Yellowish-white, amorphous powder.

Solubility in water

soluble

Solubility in water

0.27 g / 100 ml

Melting Point

-100

Melting Point

180

Boiling Point

95 - 96

Vapor Pressure

54 (25 C)

Density

1.158 g/cm3 (20 C)

Partition Coefficient

2.28

Heat Of Vaporization

32.0 kJ/mol

Usage

A na ion channel activator. Veratridine acts at neurotoxin receptor site 2 and preferentially binds to activated na ion channels causing persistent activation.

Usage

Oil and fat solvent, insecticide, nematicide.

Vapor Density

3.9

Odor threshold

23 ppm

Refractive Index

1.4388 (20 C)

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Ingestion

Severe nausea and vomiting with epigastric and substernal pain may occur.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Inhalation

Dyspnea may occur.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Skin

Sweating has been reported.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Storage

Store at -20 C in a dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause liver and kidney damage. May cause anemia. Vapors may cause dizziness or suffocation. May cause cardiac abnormalities. Symptoms of inhalation include: anorexia, abdominal pain, vomiting, blood abnormalities, and hematuria.

Skin

Causes skin irritation. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. May be absorbed through the skin.

Eyes

Causes moderate eye irritation. Vapors cause eye irritation. May cause eye injury.

Ingestion

May be harmful if swallowed. May cause effects similar to those of acute inhalation. Causes gastrointestinal tract irritation.

Hazards

Liquid is heavier than water. Vapor is heavier than air (vapor-air density at 100 deg f, 1.4) and may travel considerable distance to source of ignition and flash back.

EC Risk Phrase

R 11 20/22

EC Safety Phrase

S 16 24

UN (DOT)

1279

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

salivation, muscular weakness, and syncope may occur. Coma may occur in severe cases. Headache, aphasia, and seizures are uncommon effects of intoxication.

Exposure Effects

Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.

Exposure limit(s)

OSHA PEL: TWA 75 ppm (350 mg/m3) NIOSH REL: Ca See Appendix A NIOSH IDLH: Potential occupational carcinogen 400 ppm

Poison Class

3

Fire Fighting Measures

Flash Point

4

Autoignition

557

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.

Upper exp. limit

14.5

Lower exp. limit

3.4

Fire Potential

Flammable liquid and vapor. Vapors may travel to ignition source and flash back. Does not catch fire readily in industrial applications.

Fire Potential

Slight fire hazard.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Oxidizing agents, acids, , aluminum, orthodichlorobenzene + ethylene dichloride + aluminum. Will attack some forms of plastic, rubber, and coatings.

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, phosgene, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Toxic and irritating gases may be generated.

Transport Information

UN Number

1279

Hazard Class

3

Packing Group

II