Product Identification

Product Name

9-Chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate

Synonyms

Mometasone 17-(2-furoate)
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11-beta,16-alpha)

CAS

83919-23-7

Formula

C27H30Cl2O6

Molecular Weight

521.44000000000005

RTECS

TU3822000

Merck

12,6324

Beilstein/Gmelin

4340538

Physical and Chemical Properties

Appearance

Distributed as 0.1% ointment with a petrolatum base.

Solubility in water

Insoluble

Melting Point

218 - 220

Vapor Pressure

4.5E-18 (25 C)

Density

1.37 g/cm3 (20 C)

pKa/pKb

13.05 (pKa)

Partition Coefficient

4.27

Usage

Anti-inflammatory.

First Aid Measures

Ingestion

Give two glasses of water and induce vomiting. Never give anything by mouth to an unconscious person.

Inhalation

Supply fresh air. If required, provide artificial respiration. Keep patient warm. Seek immediate medical advice.

Skin

Wash thoroughly with soap and water.

Eyes

Flush with plenty of water for at least 15 minutes.

Handling and Storage

Storage

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers.

Exposure Controls/Personal Protection

Personal Protection

Protective work clothing. Chemical protective gloves. Safety glasses or goggles.

Exposure Effects

May cause irritation of the eyes and skin. May cause reversible suppression of the Hypothalamic-Pituitary-Adrenal Axis, symptoms of Cushing’s Syndrome, hyperglycemia and glycosuria if ingested.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Wear self-contained respirator. Wear fully protective impervious suit.

Accidental Release Measures

Small spills/leaks

Assure slippery conditions are nullified. Add sand or dirt. Scoop up and remove, Wash area with soap and water.

Stability and Reactivity

Incompatibilities

Oxidizing agents, bases.

Stability

Stable if stored as directed.

Combustion Products

May emit toxic fumes.