Product Identification

Product Name

D-Serine

Synonyms

(2R)-2-Amino-3-hydroxypropanoic acid
(R)-Serine

CAS

312-84-5

Formula

C3H7NO3

Molecular Weight

105.09

EINECS

206-229-4

Merck

12,8604

Beilstein/Gmelin

1721403

Beilstein Reference

4-04-00-03118

Physical and Chemical Properties

Appearance

White solid.

Solubility in water

Very soluble

Melting Point

235

pKa/pKb

2.16 (pKa)

Partition Coefficient

-1.75

Usage

The l-form is one of the 20 naturally occurring proteinogenic amino acids. The d form serves as a neuronal signal by activating nmda receptors in the brain.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Wash thoroughly after handling. Avoid contact with skin and eyes. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.