Product Identification

Product Name

Carbamazepine

Synonyms

5-Carbamoyl-5H-dibenz(b,f)azepine
5-Carbamoyldibenzo(b,f)azepine
5H-Dibenz(b,f)azepine-5-carboxamide
Carbazepine
Dibenz(b,f)azepine-5-carboxamide
Telesmin

CAS

298-46-4

Formula

C15H12N2O

Molecular Weight

236.27

EINECS

206-062-7

RTECS

HN8225000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,1826

Beilstein/Gmelin

1246090

Beilstein Reference

5-20-08-00247

Physical and Chemical Properties

Appearance

Crystals from absorption in ethanol + benzene.

Solubility in water

Insoluble

Melting Point

190 - 192

Boiling Point

411

Vapor Pressure

6E-7 (25 C)

Density

1.296 g/cm3 (-115 C)

pKa/pKb

13.94 (pKa)

Partition Coefficient

2.67

Heat Of Vaporization

66.3 kJ/mol

Usage

Medication.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Ataxia, slurred speech, nystagmus, dystonias, and varying degrees of CNS depression are common. Myoclonic activity, seizures and abnormal tendon reflexes have been reported. Cyclic coma, possibly due to delayed absorption, has been reported.

Fire Fighting Measures

Flash Point

202

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.