Product Identification

Product Name

(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Synonyms

3,4-Dimethoxybenzoic acid
Condylox
Dimethylprotocatechuic acid
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-
Podofilox

CAS

518-28-5

CAS

93-07-2

Formula

C22H22O8

Formula

C9H10O4

Molecular Weight

414.41

Molecular Weight

182.18

EINECS

202-215-7

EINECS

208-250-4

RTECS

DG8598750

RTECS

LV2500000

RTECS Class

Mutagen

RTECS Class

Drug; Mutagen; Reproductive Effector; Natural Product

Merck

12,10086

Merck

12,7704

Beilstein/Gmelin

518285

Beilstein/Gmelin

99163

Beilstein Reference

5-19-10-00666

Beilstein Reference

4-10-00-01460

Physical and Chemical Properties

Appearance

Light yellow-beige powder.

Appearance

Off-white powder.

Solubility in water

Very soluble

Solubility in water

Insoluble

Melting Point

117 - 119

Melting Point

188 - 189

Boiling Point

303

Vapor Pressure

0.00042 (25 C)

Density

1.436 g/cm3 (-100 C)

pKa/pKb

13.42 (pKa)

pKa/pKb

4.35 (pKa)

Partition Coefficient

1.99

Heat Of Vaporization

57.4 kJ/mol

Heat Of Combustion

-4256 kJ/mol

Usage

Cytostatic (antimitotic) glucoside.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

May cause eye irritation.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Keep containers tightly closed.

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause gastrointestinal tract damage.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

Causes irritation of the mucous membrane and upper respiratory tract.

Skin

Causes skin irritation. Harmful if absorbed through the skin. Substance is readily absorbed through the skin.

Eyes

Causes eye irritation. May cause chemical conjunctivitis.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 36/37/38

EC Safety Phrase

S 26 36

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Flash Point

121

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

4

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, strong acids, strong bases.

Decomposition

Carbon monoxide, carbon dioxide.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III

HS Code

2918 90 90