Product Identification

Product Name

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine

Synonyms

5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
Adepress
Adepril
Amitryptyline
Damilen
Damitriptyline

CAS

50-48-6

Formula

C20H23N

Molecular Weight

277.41000000000003

EINECS

200-041-6

RTECS

HO9275000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,511

Beilstein/Gmelin

2217885

Physical and Chemical Properties

Solubility in water

9.71 mg/L @ 24 C

Melting Point

196-197

pKa/pKb

9.4 (pKa)

Partition Coefficient

4.6

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Respiratory depression is common with significant overdoses and may develop rapidly. Atelectasis, aspiration pneumonitis, pneumonia and ARDS may develop in patients with severe overdose.

Eyes

Mydriasis, blurred vision and dry mouth are common anticholinergic effects. Nystagmus may occur.

Ingestion

Bowel ischemia, pseudo-obstruction and esophageal spasm have been associated with overdose. Decreased GI motility and delayed gastric emptying are common anticholinergic effects. Pancreatitis is a rare effect of overdose.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Respiratory depression may occur rapidly after overdose. Both elevated body temperature and reduced body temperature have been reported. Abnormally low blood pressure occurs with severe overdose. Rapid heart rate is a common anticholinergic effect. CNS depression, lethargy, disorientation, and ataxia are common.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.