Product Identification

Product Name

(1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

Synonyms

(85-Cis)-10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-methoxy-5,12-Naphthacenedione
(8S)-10-((4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
ADM
Adriamycin
Adriblastin
Adriblastina

CAS

23214-92-8

Formula

C27H29NO11

Molecular Weight

543.53

EINECS

245-495-6

RTECS

AV9800000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant

Merck

12,3495

Beilstein/Gmelin

1445811

Physical and Chemical Properties

Appearance

Orange powder.

Solubility in water

2%

Melting Point

216

pKa/pKb

8.33 (pKa)

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.

Hazards Identification

Inhalation

Causes respiratory tract irritation. May cause allergic respiratory tract irritation. Can produce delayed pulmonary edema.

Skin

Doxorubicin has irritant properties. Severe ulceration and necrosis may occur from extravasation.

Eyes

Causes eye irritation. May cause chemical conjunctivitis.

Ingestion

Nausea, vomiting, and diarrhea may occur.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic

Exposure Effects

Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. May cause allergic skin reaction in some individuals.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.