Product Identification

Product Name

1H-Pyrazolo[3,4-d]pyrimidin-4-ol

Synonyms

1,2Ddihydropyrazolo[4,3-e]pyrimidin-4-one
1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one
Allopurinol(I)
Allozym
Allural
Zyloprim

CAS

315-30-0

Formula

C5H4N4O

Molecular Weight

136.11000000000001

EINECS

206-250-9

RTECS

UR0785000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,287

Beilstein/Gmelin

133199

Beilstein Reference

4-26-00-02076

Physical and Chemical Properties

Appearance

Odorless tasteless white microcrystalline powder.

Solubility in water

Slightly soluble

Melting Point

>350

Density

1.635 g/cm3

pKa/pKb

9.4 (pKa)

Usage

Medication.

Vapor Density

4.69

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause irritation and dermatitis.

Eyes

May cause eye irritation.

Ingestion

May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause blood abnormalities. Ingestion of large amounts may cause liver and/or kidney damage.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Repeated exposure may cause sensitization dermatitis. Effects may be delayed.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.