Product Identification

Product Name

(+)-Pilocarpine hydrochloride

Synonyms

2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S,4R)-
2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-
Adsorbocarpine
Pilocarpine muriate
Pilovisc
Salagen

CAS

54-71-7

Formula

C11H17ClN2O2

Molecular Weight

244.75

EINECS

200-212-5

RTECS

TK1450000

RTECS Class

Drug; Reproductive Effector; Human Data

Beilstein/Gmelin

4034491

Physical and Chemical Properties

Appearance

odorless white to off-white crystalline powder

Melting Point

202

Usage

Miotic. Used to reduce the eye of the pupil during the treatment of glaucoma.

First Aid Measures

Ingestion

SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE. Wash mouth out with water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container. Store protected from light.

Handling

Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.

Hazards Identification

Ingestion

May be fatal if swallowed. May cause irritation of the digestive tract.

Inhalation

May be fatal if inhaled. May cause respiratory tract irritation.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Hazards

Contact with metals may evolve flammable hydrogen gas.

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Avoid runoff into storm sewers and ditches which lead to waterways. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions.

Stability and Reactivity

Stability

Stable under normal shipping and handling conditions.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, oxides of chlorine.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III