Product Identification

Product Name

3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid

Synonyms

17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7b-diol
3a,7b-Dihydroxy-5b-cholanic acid
7b-Hydroxylithocholic acid
Actigall
Ursodesoxycholic acid
Ursofalk

CAS

128-13-2

Formula

C24H40O4

Molecular Weight

392.57

EINECS

204-879-3

RTECS

FZ2000000

RTECS Class

Drug; Mutagen; Reproductive Effector

Merck

12,10026

Beilstein/Gmelin

3219888

Beilstein Reference

4-10-00-01604

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

205

Boiling Point

547

Vapor Pressure

3E-14 (25 C)

pKa/pKb

4.76 (pKa)

Partition Coefficient

4.66

Heat Of Vaporization

95.0 kJ/mol

Usage

Anticholelithic. Used in the treatment of gallstone disease. It is taken by mouth to dissolve the gallstones.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause irritation of the digestive tract.

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Flash Point

299

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Carbon monoxide, carbon dioxide, acrid smoke and fumes.