Product Identification

Product Name

o-Anisidine

Synonyms

2-Aminoanisole
2-Methoxyaniline
2-Methoxybenzenamine
o-Methoxyaniline

CAS

90-04-0

Formula

C7H9NO

Molecular Weight

123.16

EINECS

201-963-1

RTECS

BZ5410000

RTECS Class

Tumorigen; Mutagen

Merck

13,670

Beilstein/Gmelin

386210

Beilstein Reference

4-13-00-00806

EC Index Number

612-035-00-4

EC Class

Carcinogenic Category 2; Mutagenic Category 3; Toxic

Physical and Chemical Properties

Appearance

Red or yellow oily liquid with an amine-like odor becomes brownish on exposure to air.

Solubility in water

Slightly soluble

Melting Point

5

Boiling Point

225

Vapor Pressure

0.09 (25 C)

Density

0.966 g/cm3 (13 C)

pKa/pKb

9.48 (pKb6

Partition Coefficient

1.18

Heat Of Vaporization

46.2 kJ/mol

Heat Of Combustion

-3995 kJ/mol

Usage

Intermediate in the manufacturing of dyes, pharmaceuticals, and fragrances.

Vapor Density

4.25

Saturation Concentration

131.6 ppm (0.013%) at 27 C (calculated)

Refractive Index

1.5688 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if symptoms occur.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get on skin or in eyes. Do not ingest or inhale.

Hazards Identification

Inhalation

May cause severe allergic respiratory reaction. May cause respiratory tract irritation.

Skin

May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion.

Eyes

Causes severe eye irritation.

Ingestion

May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 45 68 23/24/25

EC Safety Phrase

S 53 45

UN (DOT)

2431

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause cancer according to animal studies.

Exposure limit(s)

NIOSH REL: Ca 0.5 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen 50 mg/m3

Poison Class

1*

Fire Fighting Measures

Flash Point

100

Autoignition

437

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

This chemical is combustible.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.

Stability and Reactivity

Disposal Code

9

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2431

Hazard Class

6.1

Packing Group

III

HS Code

2922 22 00