Product Identification

Product Name

Aconitine

Synonyms

2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine-4,8,9,11,11a(1H,7H)-pentol, 1-ethyldecahydro-6,10,13-trimethoxy-3-(methoxymethyl)-, 11a-acetate 8-benzoate
Acetylbenzoylaconine
Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1a,3a,6a,14a,15a,16b)-
Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-

CAS

302-27-2

Formula

C34H47NO11

Molecular Weight

645.75

EINECS

206-121-7

RTECS

AR5960000

RTECS Class

Human Data; Natural Product

Merck

13,120

Beilstein/Gmelin

74608

Beilstein Reference

5-21-06-00310

EC Index Number

614-008-00-2

Physical and Chemical Properties

Appearance

White crystalline solid.

Solubility in water

0.26 g/L (15 C)

Melting Point

198 - 199

pKa/pKb

5.88(at 25℃) (pKa)

Usage

Neurotoxin.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be fatal if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be fatal if absorbed through skin. Readily absorbed through skin.

Eyes

May cause eye irritation.

Ingestion

May be fatal if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

26/28

EC Safety Phrase

24 45

UN (DOT)

1544

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves.

Respirators

Government approved respirator.

Exposure Effects

Very toxic by inhalation, in contact with skin and if swallowed. Readily absorbed through skin. Target organ(s): Nerves. Heart.

Poison Class

1

Fire Fighting Measures

Fire Fighting

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

Non-Combustible

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, Strong bases.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1544

Hazard Class

6.1

Packing Group

I