Product Identification

Product Name

2-Hydroxy-2-phenylacetophenone

Synonyms

2-Hydroxy-1,2-diphenylethanone
2-Hydroxy-2-phenylacetophenone
Benzoylphenyl carbinol

CAS

119-53-9

Formula

C14H12O2

Molecular Weight

212.25

EINECS

204-331-3

RTECS

DI1590000

RTECS Class

Tumorigen; Mutagen

Merck

13,1094

Beilstein/Gmelin

391839

Beilstein Reference

4-08-00-01279

Physical and Chemical Properties

Appearance

Slightly acrid taste. When broken the fresh surfaces have a milky-white color.

Solubility in water

300 mg/L

Melting Point

130 - 132

Boiling Point

344

Vapor Pressure

3E-5 (25 C)

Density

1.31 g/cm3 (20 C)

pKa/pKb

12.28 (pKa)

Partition Coefficient

2.45

Heat Of Vaporization

61.9 kJ/mol

Usage

In organic syntheses.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Acute effects - cough, sore throat. Irritates eyes, skin and respiratory tract.

Skin

Redness

Eyes

Redness

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Protective gloves. Safety goggles.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Exposure Effects

The toxological properties of this substance have not been fully investigated.

Poison Class

3

Fire Fighting Measures

Flash Point

155

Autoignition

182

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Disposal Code

3

Stability

No data.

Incompatibilities

Sensitive to heat and light Incompatible with oxidizers.

Transport Information

HS Code

2914 40 90