Product Identification

Product Name

3-(4-Bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine

Synonyms

1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
2-Bromopheniramine
2-Pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-
3-(4-Bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
Parabromodylamine

CAS

86-22-6

Formula

C16H19BrN2

Molecular Weight

319.24

EINECS

201-657-8

Merck

12,1467

Beilstein/Gmelin

217066

Beilstein Reference

5-22-10-00490

Physical and Chemical Properties

Appearance

Oily liquid with slightly yellow color. Characteristic amine-like.

Solubility in water

Insoluble

Boiling Point

147 - 152 (0.5 torr)

pKa/pKb

4.67 (pKb)

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Pneumonitis, chest tightness, and wheezing have been reported.

Skin

Skin may be flushed, warm and dry after overdose.

Eyes

Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use.

Ingestion

Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur .

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

Sensitive to light maleate.

Incompatibilities

Strong oxidizing agents.