Product Identification

Product Name

Andrographolide

Synonyms

(3E,4S)-3-[2-[(1S,4aS,5R,6R,8aR)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decalin-1-yl]ethylidene]-4-hydroxy-oxolan-2-one
3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene- 1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5- alpha,6-alpha,8a-alpha))-2(3H)-furanone
Andrographis

CAS

5508-58-7

Formula

C20H30O5

Molecular Weight

350.46

EINECS

226-852-5

RTECS

LU3490750

RTECS Class

Drug; Natural Product

Merck

13,638

Beilstein/Gmelin

42762

Beilstein Reference

4-18-00-02357

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

231 - 232

Boiling Point

557

Vapor Pressure

1E-14 (25 C)

Density

1.21 g/cm3

pKa/pKb

12.32 (pKa)

Heat Of Vaporization

96.4 kJ/mol

Usage

May boost immune response.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Hazards

Emits toxic fumes under fire conditions.

EC Safety Phrase

22 24/25

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.

Fire Fighting Measures

Flash Point

196

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide.