Product Identification

Product Name

3,4,5-Trihydroxybenzoic acid propyl ester

Synonyms

NIPA 49
Nipagallin p
n-Propyl 3,4,5-trihydroxybenzoate
n-Propyl gallate
Progallin p
Propyl 3,4,5-trihydroxybenzoate

CAS

121-79-9

Formula

C10H12O5

Molecular Weight

212.2

EINECS

204-498-2

RTECS

LW8400000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector

Merck

12,8044

Beilstein/Gmelin

1877976

Beilstein Reference

4-10-00-02003

EC Index Number

607-198-00-3

EC Class

Harmful; Sensitising

Physical and Chemical Properties

Appearance

Fine white to creamy-white crystalline powder. Odorless or with a faint odor. Slightly bitter taste.

Solubility in water

3.5 g/L (25 C)

Melting Point

145 - 148

Boiling Point

449

Vapor Pressure

1E-8 (25 C)

Density

1.21 g/cm3 (20 C)

pKa/pKb

7.82 (pKa)

Partition Coefficient

2.6

Heat Of Vaporization

75.4 kJ/mol

Usage

Antioxidant or synergist to retard or prevent rancidity in lard & other edible fats & oils, laboratory reagent.

Refractive Index

1.5204 (167 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

EC Risk Phrase

R 22 43

EC Safety Phrase

S 24 37

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Repeated or prolonged exposure may cause allergic reactions in sensitive individuals.

Poison Class

4

Fire Fighting Measures

Flash Point

181

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This chemical is combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong bases, strong oxidizing agents, strong reducing agents, strong acids.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

HS Code

2918 29 50