Product Identification

Product Name

Acemetacin

Synonyms

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid

CAS

53164-05-9

Formula

C21H18ClNO6

Molecular Weight

415.83

EINECS

258-403-4

RTECS

NL3521400

RTECS Class

Drug; Reproductive Effector

Merck

12,27

Beilstein/Gmelin

501672

Beilstein Reference

5-22-05-00241

Physical and Chemical Properties

Solubility in water

Slightly soluble

Boiling Point

637

Vapor Pressure

4E-17 (25 C)

pKa/pKb

2.60 (pKa)

Heat Of Vaporization

98.9 kJ/mol

Usage

An nsaid that specifically potentiates the cytoxicity of anthracyclines.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Hazards Identification

Inhalation

TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.

Skin

Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.

Eyes

See Inhalation.

Ingestion

See Inhalation.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

26/27/28

EC Safety Phrase

22 25 36/37/39 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Exposure Effects

Very toxic by inhalation, in contact with skin and if swallowed.

Fire Fighting Measures

Flash Point

339

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

II