Product Identification

Product Name

2-(4-Thiazolyl)-benzimidazole

Synonyms

4-(2-Benzimidazolyl)thiazole
Apl-luster
Biogard
Bovizole
Captan t
Eprofil

CAS

148-79-8

Formula

C10H7N3S

Molecular Weight

201.25

EINECS

205-725-8

RTECS

DE0700000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector; Human Data

Merck

12,9426

Beilstein/Gmelin

611403

EC Index Number

613-054-00-0

EC Class

Dangerous for the Environment

Physical and Chemical Properties

Appearance

White or cream-colored odorless, tasteless powder. Fluoresces in acidic solution.

Solubility in water

3.84% @ pH 2.2

Melting Point

304-305

Vapor Pressure

.000000004

Partition Coefficient

1.94

Usage

Fungicide.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Thiabendazole tablets and oral suspension should be stored in tight containers.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Symptoms of exposure to this compound include anorexia, nausea, vomiting, epigastric distress, vertigo, pruritus, skin rashes, diarrhea, headache, fatigue, drowsiness, hyperglycemia, xanthopsia, leukopenia, bradycardia, hypotension, crystalluria and erythema multiforme. Other symptoms include dry eyes, dry mouth, cholestatic jaundice, hypersensitivity, jaundice, parenchymal liver damage, giddiness, numbness, hyperirritability, convulsions, collapse, psychic disturbances, tinnitus, abnormal sensation in eyes, blurring of vision, hematuria, enuresis, malodor of the urine, facial flush, chills, conjunctival injection, angiodema, anaphylaxis and lymphadenopathy. Exposure may also cause fever, itching, body odor, hypotension and fainting. Central nervous system depression may occur. Decrease in pulse rate and systolic blood pressure and perianal rash may also occur.

Skin

See inhalation.

Eyes

Color vision disturbances and tinnitus have been reported during therapeutic use of thiabendazole.

Ingestion

Nausea, vomiting, diarrhea, and anorexia are common side effects.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Exposure Effects

Fever is an idiosyncratic reaction with mebendazole. mental status changes (drowsiness, dizziness, irritability) and headaches have been reported during therapeutic use; one case of seizures and one case of guillain-barre syndrome have been reported.

Poison Class

4

Fire Fighting Measures

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Incompatibilities

Incompatible with a number of pesticides, including copper-containing fungicides, and with highly alkaline materials.

Stability

Non-volatile @ room temperature; stable in water and in acid and alkaline solution; stable under normal conditions to hydrolysis, light and heat.