Product Identification

Product Name

4,4'-Diaminodiphenyl ether

Synonyms

4-(4-Aminophenoxy)aniline
4,4'-Oxydianiline
4-Aminophenyl ether
bis(4-Aminophenyl) ether
di(4-Aminophenyl) ether
Oxydianiline

CAS

101-80-4

Formula

C12H12N2O

Molecular Weight

200.24

EINECS

202-977-0

RTECS

BY7900000

RTECS Class

Tumorigen; Mutagen

Beilstein/Gmelin

475735

Beilstein Reference

4-13-00-01038

EC Index Number

612-199-00-7

EC Class

carcinogenic, harmful

Physical and Chemical Properties

Appearance

Odorless colorless crystals or an odorless fine, beige powder (NTP, 1999).

Solubility in water

Slightly soluble

Melting Point

184

Boiling Point

389

Vapor Pressure

3E-5 (25 C)

pKa/pKb

8.52 (pKb)

Partition Coefficient

.51

Heat Of Vaporization

63.9 kJ/mol

Usage

Chemical intermediate for polyimide & poly(ester-imide) resins.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Dyspnea and tachypnea may occur.

Skin

Central cyanosis unresponsive to oxygen therapy is classic.

Ingestion

Nausea and vomiting may occur.

EC Risk Phrase

R 45 22

EC Safety Phrase

S 53 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.

Respirators

Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

Exposure Effects

CNS effects include headache, dizziness, altered mental status, confusion (lethargy progressing coma), seizures, syncope; occur secondary to CNS hypoxia, usually with levels > 20%.

Exposure limit(s)

OSHA: Possible Select carcinogen

Fire Fighting Measures

Flash Point

218

Autoignition

490

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be use.

Fire Potential

This chemical is combustible.

Accidental Release Measures

Small spills/leaks

If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Disposal Code

9

Stability

No data.

Transport Information

UN Number

2811

HS Code

2922 29 00