Product Identification

Product Name

[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride

Synonyms

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
Achromycin hydrochloride
Cyclopar
Polycycline hydrochloride
Tetracyn
Vetquamycin 324

CAS

64-75-5

Formula

C22H25ClN2O8

Molecular Weight

480.94

EINECS

200-593-8

RTECS

QI9100000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product

Beilstein/Gmelin

3844873

Beilstein Reference

4-14-00-02625

Physical and Chemical Properties

Appearance

Crystals or fine bright yellow powder.

Solubility in water

Soluble

Melting Point

223

Usage

A broad-spectrum polyketide antibiotic produced by the streptomyces genus of actinobacteria.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from moisture. Store protected from light. Store under an inert atmosphere.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Handle under an inert atmosphere. Store protected from air. Do not allow contact with water. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Excessive inhalation may cause minor respiratory irritation. May cause effects similar to those described for ingestion.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

Dust may cause mechanical irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Substance may cause hypersensitivity reactions and liver, teeth and bone

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause fetal effects.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use agent most appropriate to extinguish fire. Do NOT get water inside containers. In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere. Do not get water inside containers.

Stability and Reactivity

Incompatibilities

Air, moisture, oxidizing agents.

Stability

Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.