Product Identification

Product Name

1,2-Benzisothiazol-3(2H)-one 1,1-dioxide

Synonyms

1,2-Benzisothiazol-3(2H)-one 1,1-dioxide
1,2-Dihydro-2-ketobenzisosulfonazole
Anhydro-o-sulfaminebenzoic acid
o-Benzoic sulfimide
Saccharin acid
Saccharinose

CAS

81-07-2

Formula

C7H5NO3S

Molecular Weight

183.19

EINECS

201-321-0

RTECS

DE4200000

RTECS Class

Tumorigen; Mutagen; Reproductive Effector

Merck

12,8463

Beilstein/Gmelin

6888

Beilstein Reference

4-2700-02649

Physical and Chemical Properties

Appearance

White crystals. Odorless or faintly aromatic odor. Sweet taste.

Solubility in water

3.3 g/L

Melting Point

225 - 227

Boiling Point

sublimes

Density

0.828 g/cm3 (20 C)

pKa/pKb

1.31 (pKa)

Partition Coefficient

.91

Usage

Non-caloric synthetic sweetener.

Refractive Index

1.5878 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Wash mouth out with water. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

May cause cancer according to animal studies. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects.

Exposure limit(s)

OSHA: Possible Select carcinogen.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

HS Code

2925 11 00