Product Identification

Product Name

(+)-Griseofulvin

Synonyms

7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
Amudane
Fulvistatin
Polygris
Sporostatin
Xuanjing

CAS

126-07-8

Formula

C17H17ClO6

Molecular Weight

352.77

EINECS

204-767-4

RTECS

WG9800000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product

Merck

12,4571

Beilstein/Gmelin

95226

Beilstein Reference

5-18-05-00150

Physical and Chemical Properties

Appearance

White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless.

Solubility in water

Insoluble

Melting Point

218 - 222

Boiling Point

570

Vapor Pressure

5E-13 (25 C)

Density

1.4 g/cm3

Partition Coefficient

2.36

Heat Of Vaporization

85.6 kJ/mol

Usage

Medication, fungicide.

First Aid Measures

Ingestion

Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

Handling and Storage

Storage

Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Symptoms of exposure to this compound may include urticaria, headaches, confusion, dizziness, nausea, diarrhea, photosensitivity and leukopenia. Other symptoms may include epigastric distress, fever and arthralgia. It may cause renal damage and porphyria. It may also cause peripheral neuritis, syncope and blurred vision. Exposure has caused skin rashes, fatigue, proteinuria and, rarely, angioneurotic edema, paresthesia and lupus erythematosus. Symptoms may include dryness of the mouth, an altered sensation of taste, gastrointestinal disturbances, severe allergic reactions, erythema multiforme, exfoliative dermatitis, candidiasis, depression, irritability and, rarely, hepatitis.

Skin

See inhalation.

Eyes

See inhalation

Ingestion

See inhalation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Exposure Effects

headache, dizziness, disorientation, lethargy, fatigue, and mental confusion may be noted. Paresthesia secondary to peripheral neuropathy has been reported following therapeutic use. Use in pregnancy is contraindicated. Griseofulvin is classified as FDA pregnancy category C. There is no data concerning breast milk.

Exposure limit(s)

OSHA: Possible Select carcinogen

Fire Fighting Measures

Flash Point

228

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.