Product Identification

Product Name

N-Acetyl-L-(+)-cysteine

Synonyms

Broncholysin
l-alpha-Acetamido-beta-mercaptopropionic acid
n-Acetyl-3-mercaptoalanine
n-Acetylcysteine
n-Acetyl-L-Cysteine
n-Acetyl-n-Cysteine

CAS

616-91-1

Formula

C5H9NO3S

Molecular Weight

163.19

EINECS

210-498-3

RTECS

HA1660000

RTECS Class

Human Data

Merck

13,90

Beilstein/Gmelin

1724426

Beilstein Reference

4-04-00-03160

Physical and Chemical Properties

Appearance

White crystals. Slight acetic odor.

Solubility in water

200 g/L

Melting Point

108 - 110

Boiling Point

371

Density

1.48 g/cm3

pKa/pKb

3.24 (pKa)

Partition Coefficient

-.99

Usage

Mucolytic agent (adjuvant) for bronchopulmonary disorders.

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. Low hazard for usual industrial handling.

Skin

May cause skin irritation.

Eyes

May cause eye irritation and possible damage.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Fever may occur. Elevated blood pressure or abnormally low blood pressure may occur during an anaphylactoid reaction. with therapeutic use - dizziness during an anaphylactoid reaction has been reported. Elevated intracranial pressure during inhalational nac therapy has been reported. Seizures have been reported in laboratory animals.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Use extinguishing media most appropriate for the surrounding fire.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Heavy metals, heavy metal salts, strong oxidizers.

Stability

Stable under normal temperatures and pressures.

Decomposition

Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

HS Code

2930 90 16