Product Identification

Product Name

Isopropyl phenylcarbamate

Synonyms

isopropil-n-fenil-carbammato
isopropyl-n-fenyl-carbamaat
Propan-2-yl N-phenylcarbamate
Propham
Triherbide

CAS

122-42-9

Formula

C10H13NO2

Molecular Weight

179.22

EINECS

204-542-0

RTECS

FD9100000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector; Human Data

Merck

12,8001

Beilstein/Gmelin

2209666

Beilstein Reference

4-12-00-00620

Physical and Chemical Properties

Appearance

Colorless crystalline solid.

Solubility in water

practically insoluble

Melting Point

90

Boiling Point

87-89 (0.005 torr)

Density

1.09 g/cm3 (20 C)

Partition Coefficient

2.6

Usage

Herbicide, plant growth regulator.

First Aid Measures

Ingestion

Ipecac-induced vomiting is not recommended because of the potential for cns depression and seizures. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Intravenous fluids may be useful in restoring extracellular fluid volume following severe vomiting and diarrhea.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.

Skin

Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.

Eyes

Immediately flush with running water for at least 20 minutes.

Handling and Storage

Storage

Keep in well ventilated area.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Respiratory failure, requiring ventilatory support, has been reported following ingestions.

Skin

Exposure to dusts, sprays, solutions, wettable powder suspensions or emulsions of these agents may lead to skin and mucous membrane irritation.

Eyes

See Inhalation.

Ingestion

Nausea, vomiting and diarrhea may occur.

UN (DOT)

2757

Exposure Controls/Personal Protection

Personal Protection

Self-contained breathing apparatus must be worn. Rubber gloves, hats, suits and boots must be worn.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Exposure Effects

Exposure to thiram or mbdt-carb (based on animal studies) may cause weakness, ataxia, ascending paralysis and hypothermia. Peripheral neuropathy (pain, numbness and weakness of the extremities) has been noted following exposure to thiuram (the ethyl analog of thiram). No adverse reproductive effects (testicular parameters) in male mice were observed following methyl thiophanate doses up to 1000 mg/kg orally for 5 consecutive days (Traina et al, 1998). Maternal toxicity was evident in female rats.

Poison Class

4

Fire Fighting Measures

Fire Fighting

Use method most appropriate to fight surrounding fire.

Fire Potential

Nonflammable.

Accidental Release Measures

Small spills/leaks

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.

Stability and Reactivity

Incompatibilities

Incompatible with strong acids and bases, and especially

Stability

Stable.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2757

Hazard Class

6.1

Packing Group

I; II; III