Product Identification

Product Name

1,3,5-Estratriene-3,17beta-diol

Synonyms

17b-Estradiol
Oestradiol

CAS

50-28-2

Formula

C18H24O2

Molecular Weight

272.39

EINECS

200-023-8

RTECS

KG2975000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone

Merck

13,3738

Beilstein/Gmelin

1914275

Beilstein Reference

4-06-00-06611

Physical and Chemical Properties

Appearance

The major estrogen in humans (both male and female).

Melting Point

175-178

Partition Coefficient

3.94

Usage

Plays a critical role in reproductive and sexual functioning, and also affects other organs including bone structure.

First Aid Measures

Ingestion

Seek medical assistance.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.

Skin

Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.

Eyes

Immediately flush with running water for at least 20 minutes.

Hazards Identification

Ingestion

See Inhalation.

Inhalation

TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.

Skin

Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.

Eyes

See Inhalation.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 45 48

EC Safety Phrase

S 53 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate protective gloves, clothing and goggles.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Fire Fighting Measures

Fire Fighting

Extinguish using agent most appropriate for surrounding fire.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.

Transport Information

UN Number

2811

Stability and Reactivity

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.