Product Identification

Product Name

Dilatrate-SR

Synonyms

[(3S,3aS,6R,6aS)-6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate
Cardis
Carvanil
Carvasin
Cedocard
Claodical

CAS

87-33-2

Formula

C6H8N2O8

Molecular Weight

236.14

EINECS

201-740-9

RTECS

LZ4385000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck

12,5245

Beilstein/Gmelin

88225

Beilstein Reference

4-19-00-00998

Physical and Chemical Properties

Appearance

A crystalline solid.

Solubility in water

Insoluble

Melting Point

70

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Eyes

LOSS OF VISION - A transient loss of vision reportedly occurred before acute toxic effects from nitroglycerin exposure. Constriction of the pupil and corneal damage occurred after intravenous exposure.

Ingestion

Nausea, vomiting, colicky pain, and diarrhea may occur.

Hazards

May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form. May re-ignite after fire is extinguished.

UN (DOT)

2907

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Abnormally low blood pressure is common. Low heart rate may occur in predisposed patients; reflex rapid heart rate may occur. Death occurs secondary to circulatory collapse or respiratory failure. With therapeutic use - 1. Headache and dizziness are common, even after administration of therapeutic doses. Acute wernicke's encephalopathy from intravenous infusions may be precipitated by ethanol and propylene glycol diluents. In male rats, a dominant lethal test showed no effect on male fertility; interstitial cell tumors of rat testes were induced after nitroglycerin exposure. Results on teratogenicity in rats are conflicting.

Fire Fighting Measures

Fire Fighting

Solid streams of water may spread fire. Use water in flooding quantities as fog. Use dry chemical, graphite, or dry earth.

Fire Potential

Flammable/combustible material.

Accidental Release Measures

Small spills/leaks

Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.

Stability and Reactivity

Incompatibilities

If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation.

Stability

No data.

Transport Information

UN Number

2907