Product Identification

Product Name

Ampicillin

Synonyms

(2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
1,9-Nonanediamine
Alpen
Amfipen
Aminobenzylpenicillin
D(-)-alpha-Aminobenzylpenicillin
D-(-)-alpha-Aminopenicillin
Nonane-1,9-diamine

CAS

646-24-2

CAS

69-53-4

Formula

C16H19N3O4S

Formula

C9H22N2

Molecular Weight

158.29

Molecular Weight

349.41

EINECS

200-709-7

EINECS

211-470-3

RTECS

XH8350000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,628

Beilstein/Gmelin

1737533

Beilstein/Gmelin

629178

Beilstein Reference

4-04-00-01364

EC Class

irritant

Physical and Chemical Properties

Appearance

White solid.

Appearance

White, crystalline powder. Odorless or has a faint odor characteristic of the penicillins.

Solubility in water

1 gm dissolves in about 90 ml

Solubility in water

575 g/L (20 C)

Melting Point

35 - 38

Melting Point

202

Boiling Point

258

Vapor Pressure

0.014 (25 C)

pKa/pKb

3.03 (pKb)

pKa/pKb

2.61 (pKa)

Heat Of Vaporization

49.6 kJ/mol

Usage

Antibiotic.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Inhalation

Causes respiratory tract irritation.

Skin

Causes skin irritation.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Eyes

Causes eye irritation.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Skin

Contact dermatitis may occur due to hypersensitivity reactions.

Ingestion

Diarrhea, nausea, vomiting, and abdominal pain may occur.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 34

EC Safety Phrase

S 26 36/37/39 45

UN (DOT)

3265

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

drowsiness, myoclonus, seizures, and coma may occur following large iv doses. Neurological side effects may be more common in patients with impaired renal function.

Fire Fighting Measures

Flash Point

110

Autoignition

285

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Acids, acid chlorides, acid anhydrides, oxidizing agents.

Stability

No data.

Stability

Stable under normal temperatures and pressures. Absorbs carbon dioxide from the air.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3265

Hazard Class

8

Packing Group

I; II; III

HS Code

2921 29 00