Product Identification

Product Name

1,3,8-Trihydroxy-6-methylanthraquinone

Synonyms

1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione
1,3,8-Trihydroxy-6-methylanthraquinone
3-Methyl-1,6,8-trihydroxyanthraquinone
4,5,7-Trihydroxy-2-methylanthraquinone
Emodin
Rheum emodin

CAS

518-82-1

Formula

C15H10O5

Molecular Weight

270.24

EINECS

208-258-8

RTECS

CB7920600

RTECS Class

Tumorigen; Mutagen

Merck

12,3602

Beilstein/Gmelin

1888141

Beilstein Reference

4-08-00-03575

Physical and Chemical Properties

Appearance

Orange needles or powder.

Solubility in water

Insoluble

Melting Point

263

Boiling Point

529

Vapor Pressure

1E-11 (25 C)

pKa/pKb

6.39 (pKa)

Partition Coefficient

4.35

Heat Of Vaporization

83.4 kJ/mol

Usage

Formerly used as a laxative.

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Keep container closed when not in use.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause irritation of the digestive tract.

Inhalation

Causes respiratory tract irritation.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

288

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, carbon dioxide, acrid smoke and fumes.