Product Identification

Product Name

Dibenzo-1,4-thiazine

Synonyms

10H-Phenothiazine
Dibenzothiazine
Thiodiphenylamine

CAS

92-84-2

Formula

C12H9NS

Molecular Weight

199.28

EINECS

202-196-5

RTECS

SN5075000

RTECS Class

Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,7404

Beilstein/Gmelin

143237

Beilstein Reference

4-27-00-01214

Physical and Chemical Properties

Appearance

Greyish-green to greenish-yellow solid, slight odor.

Solubility in water

Insoluble

Melting Point

182 - 185

Boiling Point

371

Vapor Pressure

1E-5 (25 C)

Density

1.34 g/cm3 (20 C)

pKa/pKb

11.48 (pKb)

Partition Coefficient

4.15

Heat Of Vaporization

61.8 kJ/mol

Usage

Manufacture of dyes, parent compound for chlorpromazine & related antipsychotic drugs, polymerization inhibitor, antioxidant.

Saturation Concentration

Nearly zero

Refractive Index

1.6353 (212 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Causes respiratory tract irritation. May cause liver and kidney damage. May cause anemia.

Skin

Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Substance is rapidly absorbed through the skin. May cause dermatitis. Contact with the skin may cause photosensitivity.

Eyes

Causes eye irritation. May cause painful sensitization to light. Causes redness and pain.

Ingestion

May cause irritation of the digestive tract.

EC Risk Phrase

R 52/53

EC Safety Phrase

S 60

UN (DOT)

3077

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic inhalation may cause effects similar to those of acute inhalation.

Exposure limit(s)

TLV: ppm; 5 mg/m3 (as TWA) (skin) (ACGIH 1996). NIOSH REL: TWA 5 mg/m3 skin

Poison Class

3

Fire Fighting Measures

Flash Point

202

Autoignition

470

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Flammable solid. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

Although phenothiazine oxidizes fairly easily when it is exposed to air, risk of fire is not high.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.

Incompatibilities

Strong oxidizing agents - strong acids.

Decomposition

Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.

Combustion Products

if involved in fire, phenothiazine produces highly toxic sulfur and nitrogen oxides, which are dangerous lung irritants.

Transport Information

UN Number

3077

HS Code

2934 30 90