Product Identification

Product Name

5,5-Diphenylhydantoin sodium salt

Synonyms

2,4-Imidazolidinedione, 5,5-diphenyl-, monosodium salt
5,5-Diphenyhydanthoin sodium
Lepitoin sodium
Minetoin
Sodium 5,5-diphenyl-2,4-imidazolidinedione
Sodium diphenylhydantoin

CAS

630-93-3

Formula

C15H12N2NaO2

Molecular Weight

275.26

EINECS

211-148-2

RTECS

MU1400000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Beilstein/Gmelin

4221969

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Soluble.

Melting Point

292-299

pKa/pKb

8.06 (pKa)

Heat Of Vaporization

Usage

Medication (vet), recommended for epileptic seizures in dogs.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area. Chemical carcinogens store below 40C, preferably between 15 and 30C, unless otherwise specified by manufacturer. Store in a tight container. Protect from freezing.

Handling

Avoid contact. Only used in a chemical hood, while using protective equipment.

Hazards Identification

Inhalation

Nausea, dizziness, headache, ataxia, blurred vision, nystagmus, and mental confusion.

Skin

Cutaneous eruptions following phenytoin therapy are common. Purple glove syndrome has been reported following intravenous phenytoin.

Eyes

Irritation.

Ingestion

Harmful fi swallowed. Can cause gastrointestinal disturbances, nausea, slurred speach.

Exposure Controls/Personal Protection

Personal Protection

Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.

Respirators

NIOSH approved respirator.

Exposure Effects

Cerebellar ataxia, nystagmus, hyperreflexia, drowsiness, lethargy, and coma may occur. Choreoathetosis and dyskinesias have been reported. CNS depression may occur more commonly in children, and ataxia may occur more commonly in adults.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacutae area. Wear approved SCBA, rubber boots and gloves. Sweep up and place in a bag for waste disposal. Avoid reaising dust. Ventilate area. Wash spill site after pickup is complete.

Stability and Reactivity

Stability

Sensitive to light phenytoin a slight yellowing of the solution will not affect its potency. After being refrigerated, solution may form a precipitate which usually dissolves after being warmed to room temperature; however, do not use if the solution is not clear.

Incompatibilities

Strong oxidizing agents.

Decomposition

Oxides of carbon and nitrogen.