Product Identification

Product Name

N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline

Synonyms

3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
Lonzol
N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
Natrilix
Tandix
Veroxil

CAS

26807-65-8

Formula

C16H16ClN3O3S

Molecular Weight

365.84

EINECS

248-012-7

RTECS

CV2451200

RTECS Class

Drug; Reproductive Effector

Merck

12,4969

Beilstein/Gmelin

1604026

Beilstein Reference

5-20-06-00348

Physical and Chemical Properties

Solubility in water

Insoluble

pKa/pKb

9.35 (pKa)

Usage

A thiazide-like diuretic used, either alone or in combination with other drugs, to treat high blood pressure and to prevent salt and fluid retention associated with heart failure.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Exposure Effects

Avoid contact and inhalation. Target organ(s): Kidneys.

Fire Fighting Measures

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Hazards Identification

Hazards

Emits toxic fumes under fire conditions.