Product Identification

Product Name

Azodiisobutyrodinitrile

Synonyms

Echinomycin A
N-[3,11,13,16,24,26-Hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-dipropan-2-yl-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacos-21-yl]quinoxaline-2-carboxamide
NSC-526417
Quinomycin A
S-426-S (Lepetit)

CAS

512-64-1

Formula

C51H64N12O12S2

Molecular Weight

1101.27

RTECS

JW5250000

Merck

12,3545

Beilstein/Gmelin

78671

Beilstein Reference

4-27-00-09726

Physical and Chemical Properties

Appearance

Very faintly beige powder.

Solubility in water

Insoluble

Melting Point

217 - 218

Density

1.41 g/cm3 (20 C)

pKa/pKb

9.38 (pKa)

Partition Coefficient

-.67

Usage

A cytotoxic polypeptide quinoxaline antibiotic isolated from streptomyces echinatus that binds to dna and inhibits rna synthesis.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep container tightly closed. Store at 2 - 8 C.

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.

Respirators

Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.

Exposure Effects

Toxic. May cause heritable genetic damage. Toxic by inhalation, in contact with skin and if swallowed. Nausea, headache, and vomiting. Reversible liver enzyme abnormalities.

Fire Fighting Measures

Fire Fighting

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Extinguishing media: Water spray. Carbon dioxide, dry chemical powder or appropriate foam.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Oxides of carbon, nitrogen and sulfur.

Combustion Products

Emits toxic fumes under fire conditions.

Transport Information

UN Number

3462

Hazard Class

6.1

Packing Group

II

Hazards Identification

EC Risk Phrase

R: 23/24/25 46

EC Safety Phrase

S: 36/37/39 45 53

UN (DOT)

3462