Product Identification

Product Name

2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride

Synonyms

2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride
2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride
Tris (hydroxymethyl) aminomethane hydrochloride
Trizma hydrchloride

CAS

1185-53-1

Formula

C4H12ClNO3

Molecular Weight

157.6

EINECS

214-684-5

Merck

12,9902

Beilstein/Gmelin

3675235

Beilstein Reference

0-04-00-00303

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Soluble

Melting Point

149

pKa/pKb

8.1(at 25℃) (pKa)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation.

Skin

No information regarding skin irritation and other potential effects was found.

Eyes

No information regarding eye irritation and other potential effects was found.

Ingestion

The toxicological properties of this substance have not been fully investigated.

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

The toxicological properties of this substance have not been fully investigated.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, bromine.

Transport Information

HS Code

2922 19 80