Product Identification

Product Name

Temozolomide

Synonyms

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
Imidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo
M & B 39831
MB-39831
Methazolastone

CAS

85622-93-1

Formula

C6H6N6O2

Molecular Weight

194.15

RTECS

NJ5927050

Merck

12,9289

Beilstein/Gmelin

5547136

Physical and Chemical Properties

Solubility in water

Slightly soluble

Vapor Pressure

3.5E-11 (25 C)

Density

1.97 g/cm3 (20 C)

pKa/pKb

15.29 (pKa)

Partition Coefficient

-1.15

Usage

Used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor.

Handling and Storage

Storage

Store in original container in a cool dark place.

Hazards Identification

Inhalation

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.

Skin

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.

Eyes

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Ingestion

If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity

Combustion Products

Emits toxic fumes under fire conditions.