Product Identification

Product Name

5-Bromo-2'-deoxyuridine

Synonyms

2'-Deoxy-5-bromouridine
5-BDU
5-Bromo-2-deoxyuridine
5-Bromodeoxyuridine
5-Bromodesoxyuridine
Bromodeoxyuridine

CAS

59-14-3

Formula

C9H11BrN2O5

Molecular Weight

307.10000000000002

EINECS

200-415-9

RTECS

YU7350000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector

Merck

12,10433

Beilstein/Gmelin

30395

Beilstein Reference

4-24-00-01234

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

Slightly soluble

Melting Point

192 - 193

pKa/pKb

7.85 (pKa)

Usage

Makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow.

Vapor Density

10.6

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20 C).

Handling

Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.

Inhalation

May cause respiratory tract irritation. Low hazard for usual industrial handling.

Skin

May cause skin irritation. May cause erythema, and edema with crusting and scaling.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen bromide, nitrogen.