Product Identification

Product Name

2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid

Synonyms

1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-
1-Methyl-5-p-toluoylpyrrole-2-acetic acid
5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic acid
McN 2559
Tolectin
Tolmetine

CAS

26171-23-3

Formula

C15H15NO3

Molecular Weight

257.29000000000002

EINECS

247-497-2

RTECS

UX9287000

RTECS Class

Drug; Reproductive Effector

Merck

12,9655

Beilstein/Gmelin

485305

Beilstein Reference

5-22-06-00392

Physical and Chemical Properties

Appearance

Crystals from acetonitrile.

Solubility in water

Soluble

Melting Point

191

pKa/pKb

4.46 (pKa)

Partition Coefficient

2.79

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Although rare, respiratory arrest has been reported. Pulmonary fibrosis has been associated .

Skin

Photosensitivity, toxic epidermal necrolysis, erythema multiforme, and phototoxicity have been reported .

Eyes

Various ocular adverse reactions and tinnitus are frequently reported following NSAID overdoses. Bullous and erosive stomatitis has occurred in a patient taking nimesulide and diclofenac.

Ingestion

Nausea, vomiting, epigastric pain, erosive esophagitis, pancreatitis, gastrointestinal bleeding, and intestinal stenosis have been associated and/or overdose of non-steroidal antiinflammatory drugs.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Low grade fever, abnormally low blood pressure, and sinus rapid heart rate have been noted in both overdose and therapeutic use of nsaids. drowsiness, delirium, lethargy, seizures, dizziness, disorientation, loss of consciousness, tinnitus, headache, hallucinations and encephalopathy have been associated with therapeutic dosing and/or overdose of non-steroidal anti-inflammatory drugs. Coma has been reported following severe nsaid overdose. Myoclonic twitching as been reported for several days after an overdose of piroxicam and fentiazac. Use in pregnancy is not recommended. Inhibition of prostaglandin synthesis may cause closure of the ductus arteriosus. NSAIDs may prolong pregnancy if taken before the onset of labor, especially during the third trimester.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.