Product Identification

Product Name

Methylthiouracil

Synonyms

4-Hydroxy-2-mercapto-6-methylpyrimidine
6-Methyl-2-sulfanylidene-1H-pyrimidin-4-one
6-Methyl-2-thiouracil
Antibason
Thimecil

CAS

56-04-2

Formula

C5H6N2OS

Molecular Weight

142.18

EINECS

200-252-3

RTECS

YR0875000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,6210

Beilstein/Gmelin

115648

Beilstein Reference

5-24-07-00049

EC Class

harmful

Physical and Chemical Properties

Appearance

White crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic.

Solubility in water

Slightly soluble

Boiling Point

351

Density

1.519 g/cm3

Partition Coefficient

.27

Usage

Medication used in the treatment of hyperthyroidism.

First Aid Measures

Ingestion

Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Hormones and antibiotics room.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Exposure to high concentrations of mercaptans can produce unconsciousness with cyanosis, cold extremities and rapid pulse. Mercaptans may cause nausea and headache.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed. Mercaptans may cause nausea and headache. Exposure to high concentrations of mercaptans can produce unconsciousness with cyanosis, cold extremities and rapid pulse. May cause thyroid abnormalities.

EC Risk Phrase

R 45 22

EC Safety Phrase

S 53 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

May cause cancer according to animal studies. May cause thyroid abnormalities. Reproductive effects have been reported in humans.

Exposure limit(s)

OSHA: Possible Select carcinogen

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

UN Number

2811

HS Code

2933 59 95