Product Identification

Product Name

Lisinopril

Synonyms

(2S)-1-[(2S)-6-Amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid dihydrate
(S)-(-)-1-[N-(1-Carboxy-3-phenylpropyl)-L-lysinyl]-L-proline dihydrate

CAS

83915-83-7

Formula

C21H31N3O5.2H2O

Molecular Weight

441.52

RTECS

TW3589990

RTECS Class

Reproductive Effector

Merck

13,5538

Beilstein/Gmelin

4276619

Beilstein Reference

6-22

Physical and Chemical Properties

Melting Point

146 - 148

pKa/pKb

2.5, 4.0, 6.7, 10.1(at 25℃) (pKa)

Usage

Used to lower blood pressure, to treat congestive heart failure, and to improve the survival rate after a heart attack.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Safety Phrase

22 24/25

Exposure Controls/Personal Protection

Personal Protection

Protective gloves.

Respirators

Wear dust mask.

Exposure Effects

Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.

Fire Fighting Measures

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nature of decomposition products not known.