Product Identification

Product Name

4-Bromo-1-nitrobenzene

Synonyms

4-Nitrobromobenzene
4-Nitrophenyl bromide
p-Nitrobromobenzene
p-Nitrophenyl bromide

CAS

586-78-7

Formula

C6H4BrNO2

Molecular Weight

202.01

EINECS

209-583-8

RTECS

CY9040550

RTECS Class

Mutagen

Beilstein/Gmelin

636964

Beilstein Reference

4-05-00-00729

Physical and Chemical Properties

Appearance

Off-white to brown, crystalline powder.

Solubility in water

Insoluble

Melting Point

124 - 126

Boiling Point

255

Vapor Pressure

0.03 (25 C)

Density

1.948 g/cm3 (25C)

Partition Coefficient

2.55

Heat Of Vaporization

47.0 kJ/mol

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed. Do not ingest or inhale.

Hazards Identification

Inhalation

Harmful if inhaled. Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Can produce delayed pulmonary edema.

Skin

Causes skin irritation. May be absorbed through the skin in harmful amounts.

Eyes

Causes eye irritation. May cause chemical conjunctivitis.

Ingestion

Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Effects may be delayed 2 to 4 hours. May form methemoglobin which in sufficient concentration causes cyanosis.

Hazards

Containers may explode when heated.

EC Risk Phrase

R 20/21/22 33 36/38

EC Safety Phrase

S 26 36/37/39

UN (DOT)

2732

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Prolonged exposure may cause anemia and methemoglobinemia, characterized by dizziness, drowsiness, headache, breath shortness, cyanosis, rapid heart rate and chocolate-brown colored blood. Effects may be delayed. Laboratory experiments have resulted in mutagenic effects.

Fire Fighting Measures

Flash Point

106

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, strong bases.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen bromide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2732

Hazard Class

6.1

Packing Group

III

HS Code

2904 90 85