Product Identification

Product Name

Ziconotide acetate

Synonyms

omega-Conopeptide MVIIA (Conus)
omega-Conotoxin M VIIA

CAS

107452-89-1

Formula

C102H172N36O32S7

Molecular Weight

2639.13

Merck

12,10471

Physical and Chemical Properties

Appearance

White to off-white powder. Odorless.

Solubility in water

Slihtly soluble

Usage

Ligand for binding studies of voltage sensitive calcium channels.

First Aid Measures

Ingestion

If swallowed, give large quantities of water to drink and get medical attention immediately. Never give anything by mouth to an unconscious person.

Inhalation

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Wash exposed area with soap and water. Get medical advice if irritation develops.

Eyes

Wash thoroughly with running water. Get medical advice if irritation develops.

Handling and Storage

Storage

Store at or below -20C (Deep Freeze) in a desiccated environment and protected from light. Always take precautions to avoid creating airborne dust or mists. Powdered material should be handled under hooded ventilation.

Hazards Identification

Inhalation

Inhalation of dust may produce an allergic reaction. The risk of allergic sensitization increases with repeated direct exposure.

Skin

No information found, but skin contact may produce an allergic reaction. The risk of allergic sensitization increases with repeated direct exposure. Ziconotide has potent pharmacological activity and is classified as an OEB-3* material.

Ingestion

Ingestion may produce an allergic reaction. May cause central nervous system effects similar to those from therapeutic doses.

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate gloves; lab coat, nylon coveralls or disposable Tyvek suit; safety glasses, safety shoes, and disposable booties. Safety glasses. Maintain eye wash fountain and quick-drench facilities in work area.

Respirators

An air-purifying respirator (P95 or other type providing a higher level of protection) should be worn by all personnel in the immediate area in cases where non-ventilated containment is used, where significant amounts of material (e.g., more than 2 grams) are used, or where the material may become airborne (as through grinding, etc.). If using a ventilated enclosure that has not been validated, wear a half-mask respirator equipped with HEPA cartridges until the enclosure is validated for use.

Exposure Effects

Repeated contact can cause sensitization and potentially significant reactions to very small exposures. Persons with prior hypersensitivity to ziconotide should avoid exposures. May have additive central nervous system effects with alcohol or other CNS depressants consumed before or after exposure.

Fire Fighting Measures

Fire Fighting

Use any means suitable for extinguishing surrounding fire. In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Follow handling guidance appropriate for OEB-3 potent compounds.

Fire Potential

Not considered to be a fire hazard.

Accidental Release Measures

Small spills/leaks

Pick up and place in a suitable container for reclamation or disposal, using a method that does not generate dust.

Stability and Reactivity

Stability

Stable under ordinary conditions of use and storage.