Product Identification

Product Name

Fluorodeoxyuridine

Synonyms

1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil
2'-Deoxy-5-fluorouridine
Deoxyfluorouridine
FDUR
Floxuridin

CAS

50-91-9

Formula

C9H11FN2O5

Molecular Weight

246.2

EINECS

200-072-5

RTECS

YU7525000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

13,4138

Beilstein/Gmelin

90221

Beilstein Reference

5-24-06-00291

Physical and Chemical Properties

Appearance

Inhibits DNA synthesis.

Solubility in water

1 g in about 2 ml

Melting Point

153

pKa/pKb

7.44 (pKa)

Partition Coefficient

-1.16

Usage

Sustained release of large numbers of sterilized males of specific insect species has yielded remarkable control of certain insect pests of domestic animals & crop plants. Sterilization can be effected chemically, by feeding compd of known chemosterilant activity, such as fluorouracil deriv.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Stomatitis (inflamation of the mucous membranes in the mouth) is a common sign of toxicity.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 20/22 40 61

EC Safety Phrase

S 22 36/37/39 45

UN (DOT)

1760

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic ingestion may result in hair loss, nail changes, dermatitis and increased pigmentation of the skin.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam. Use agent most appropriate to extinguish fire.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, strong bases.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1760

Hazard Class

8

Packing Group

I; II; III