Product Identification

Product Name

Chlorthalidone

Synonyms

1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
2-Chloro-5-(3-hydroxy-1-oxoisoindol-3-yl)benzenesulfonamide
3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine
Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
Demi-Regroton
Natriuran

CAS

77-36-1

Formula

C14H11ClN2O4S

Molecular Weight

338.77

EINECS

201-022-5

RTECS

DB1556000

RTECS Class

Reproductive Effector; Human Data

Merck

12,2246

Beilstein/Gmelin

312295

Beilstein Reference

5-22-07-00602

Physical and Chemical Properties

Appearance

White to yellowish-white crystalline powder. Odorless.

Solubility in water

Slightly soluble

Melting Point

179

pKa/pKb

4.43 (pKb)

Usage

Therap cat (vet): diuretic.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in airtight container.

Handling

Use in hood. Wear protective equipment. Do not raise dust.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

None is normally required. If needed, a NIOSH/MSHA aproved air supplied respirator or dust respirator is advised.

Exposure Effects

Irritation. Possible allergic reation to dust. May cause dryness of mouth, increased thirst, irregular heartbeat, mood changes, muscle cramps, pain, nausea, vomiting, tiredness, weakness, weak pulse.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Wear approved protective equipment. Vacuum or sweep up spill. Avoid dust creation. Place spillage in appropriate container for disposal.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Toxic fumes.