Product Identification

Product Name

Isosorbide 5-mononitrate

Synonyms

[(3R,3aS,6S,6aR)-6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl nitrate
5-Nitro-1,4,3,6-dianhydro-D-glucitol
6-Nitroxoyhexahydrofuro[3,2-b]furan-3-ol
8-Nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol
Isosorbide mononitrate
Isosorbide-5-mononitrate

CAS

16051-77-7

Formula

C6H9NO6

Molecular Weight

191.16

EINECS

240-197-2

RTECS

LZ4386500

RTECS Class

Drug; Reproductive Effector

Beilstein/Gmelin

5851319

Beilstein Reference

6-19

Physical and Chemical Properties

Appearance

Isosorbide-5-mononitrate is a crystalline solid.

Solubility in water

Soluble

Melting Point

88-91

Usage

Drug used in the treatment of angina pectoris, acts by dilating the blood vessels so as to reduce the blood pressure.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Avoid mechanical shock and friction.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Hazards

May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form. May re-ignite after fire is extinguished.

UN (DOT)

3251

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

180

Autoignition

210

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Dust can be an explosion hazard when exposed to heat or flame. Extinguishing media: Do NOT use water directly on fire. Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Flammable/combustible material.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.

Transport Information

UN Number

3251

Hazard Class

4.1

Packing Group

III