Product Identification

Product Name

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv.

Synonyms

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
NSC 125973
Paclitaxel
Yewtaxan

CAS

33069-62-4

Formula

C47H51NO14

Molecular Weight

853.92

RTECS

DA8340700

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,7117

Beilstein/Gmelin

1420457

Physical and Chemical Properties

Appearance

Needles (from aqueous methanol) or fine white powder.

Melting Point

213 - 216

Usage

Tool in study of structure and function of microtubules.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a dry area. Deep freeze (below -20 C).

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Inhalation

May cause respiratory tract irritation. May be harmful if inhaled.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation and possible damage.

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

sensory neuropathy of the hands and feet or mouth and tongue was reported in patients taking paclitaxel or docetaxel. Symptoms include a burning dysesthesia of the feet, numbness, and lancing pain in the back or extremities. Seizures, autonomic neuropathy, motor dysfunction, proximal muscle weakness, and coma have been occasionally described. Optic nerve disturbances have been reported following paclitaxel therapy. Paclitaxel and docetaxel may be maternal and embryo-fetal toxic and are classified as FDA Pregnancy Category D. <br>Breast-feeding is not recommended due to potential risk to the nursing infant.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

No data.

Incompatibilities

Oxidizing agents.

Decomposition

Carbon monoxide, carbon dioxide.