Product Identification

Product Name

Niflumic acid

Synonyms

2-(a,a,a-Trifluoro-m-toluidino)nicotinic acid
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
2-[3-(Trifluoromethyl)anilino]nicotinic acid
2-[3-(Trifluoromethyl)phenylamino]nicotinic acid
Actol

CAS

4394-00-7

Formula

C13H9F3N2O2

Molecular Weight

282.22000000000003

EINECS

224-516-2

RTECS

QT2999100

RTECS Class

Drug; Reproductive Effector

Merck

12,6620

Beilstein/Gmelin

489360

Beilstein Reference

5-22-13-00598

Physical and Chemical Properties

Solubility in water

Slightly soluble

Melting Point

204

Boiling Point

378

Vapor Pressure

2E-6 (25 C)

pKa/pKb

1.68 (pKa)

Heat Of Vaporization

66.0 kJ/mol

Usage

Selective cyclooxygenase-2 (cox-2) inhibitor.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

Material is irritating to mucous membranes and upper respiratory tract.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

20/21/22 36/37/38

EC Safety Phrase

26 36

Exposure Controls/Personal Protection

Personal Protection

Rubber gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.

Fire Fighting Measures

Flash Point

182

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen fluoride.