Product Identification

Product Name

6-(Trifluoromethoxy)-1,3-benzothiazol-2-amine

Synonyms

2-Amino-6-trifluoromethoxybenzothiazole
2-Benzothiazolamine, 6-(trifluoromethoxy)-
6-(Trifluoromethoxy)-2-aminobenzothiazole
Benzothiazole, 2-amino-6-trifluoromethoxy-
Rilutek

CAS

1744-22-5

Formula

C8H5F3N2OS

Molecular Weight

234.2

RTECS

DL2830000

Merck

12,8389

Physical and Chemical Properties

Appearance

Powder.

Solubility in water

Insoluble

Melting Point

117

Boiling Point

296

Vapor Pressure

0.0015 (25 C)

Density

1.572 g/cm3 (20 C)

pKa/pKb

10.45 (pKb)

Partition Coefficient

2.84

Heat Of Vaporization

53.6 kJ/mol

Usage

Used to treat amyotrophic lateral sclerosis.

First Aid Measures

Ingestion

Do not induce vomiting without medical advice.

Inhalation

Move to fresh air. Call a physician immediately.

Skin

Rinse immediately with plenty of water and seek medical advice.

Eyes

In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Handling and Storage

Storage

Store at room temperature in a tightly sealed container.

Exposure Controls/Personal Protection

Personal Protection

PVC or other plastic gloves. Protective work clothing. Safety glasses with side-shields.

Exposure Effects

Chronic toxicity: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness. Local effects: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting. Specific effects: May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, headache.

Fire Fighting Measures

Flash Point

133

Fire Fighting

Extinguish using dry chemical, CO2, water spray or alcohol foam. Wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Water mist may be used to cool closed containers.

Accidental Release Measures

Small spills/leaks

Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.

Stability and Reactivity

Incompatibilities

Oxidizing and spontaneously flammable products.