Product Identification

Product Name

(+/-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine

Synonyms

3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
Deprex
dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
Fluval
N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine
Prozac

CAS

54910-89-3

Formula

C17H18F3NO

Molecular Weight

309.33

RTECS

DA8326855

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,4222

Beilstein/Gmelin

3991406

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

158

pKa/pKb

3.95 (pKb)

Partition Coefficient

3.749

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

overdose effects, in most patients, include only mild neurological symptoms. However, seizures and coma may occur. Therapeutic doses have been reported to cause dizziness, tremor, restlessness, ataxia, and syncope. Serotonin syndrome may develop after overdose or when used therapeutically with other serotonergic agents. Fluoxetine has no known teratogenic effect in humans; US FDA pregnancy category C.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Hazards Identification

Ingestion

Nausea, vomiting, and diarrhea have all been reported.